Max and Caroline on 2 Broke Girls. Max is the street smarts, while Caroline is the order and grace in this unlikely friendship. When they first met, Caroline was a spoiled kid looking for a place to crash, while Max was the tough cookie just coasting by. Together, they've made a home and built a cupcake business that’s slowly but surely taking off.

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Jake and Rosa on Brooklyn Nine-Nine. This friendship was forged in the fires of police academy. Jake may only know three facts about the extremely secretive Rosa, but they have absolute trust in each other—give or take 1,000 push-ups (see: the episode "Pontiac Bandit".

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Maya and Riley on Girl Meets World. Maya is the effortless cool to Riley's frenzied energy. They spend so much time together, usually at Riley's place, that they're so much more than best friends—they're sisters and soul mates.

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Will and Marcus on About A Boy. These neighbors were born 22 years apart, but Will’s man-child behavior mixes well with Marcus’s wisdom beyond his years. Will acts as the kid’s father/brother figure, while Marcus pushes Will to grow up just a tiny bit every day. Because of Will, Marcus has a super cool tree house, and because of Marcus, Will has an excuse to spend hours at said tree house.

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Sheldon and Leonard on The Big Bang Theory. Sheldon, with his nitpicky and childlike ways, may be a pain to live with, but Leonard can’t imagine a life without his bestie and roomie.

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Manny and Luke on Modern Family. Luke is all fun and games, while Manny is all about responsibility and decorum. These cousins play and sneak around like brothers, and fight like an old married couple.

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